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Practical approaches to effective management of intestinal radiation injury:Benefit of resectional surgery 被引量:6

Practical approaches to effective management of intestinal radiation injury:Benefit of resectional surgery
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摘要 AIM:To study the outcome of patients undergoing surgical resection of the bowel for sustained radiation-induced damage intractable to conservative management.METHODS:During a 7-year period we operated on 17 cases (5 male,12 female) admitted to our surgical department with intestinal radiation injury (IRI).They were originally treated for a pelvic malignancy by surgical resection followed by postoperative radiotherapy.During follow-up,they developed radiation enteritis requiring surgical treatment due to failure of conservative management.RESULTS:IRI was located in the terminal ileum in 12 patients,in the rectum in 2 patients,in the descending colon in 2 patients,and in the cecum in one patient.All patients had resection of the affected region(s).There were no postoperative deaths,while 3 cases presented with postoperative complications (17.7%).All patients remained free of symptoms without evidence of recurrence of IRI for a median follow-up period of 42 mo (range,6-96 mo).CONCLUSION:We report a favorable outcome without IRI recurrence of 17 patients treated by resection of the diseased bowel segment. AIM:To study the outcome of patients undergoing surgical resection of the bowel for sustained radiation-induced damage intractable to conservative management.METHODS:During a 7-year period we operated on 17 cases (5 male,12 female) admitted to our surgical department with intestinal radiation injury (IRI).They were originally treated for a pelvic malignancy by surgical resection followed by postoperative radiotherapy.During follow-up,they developed radiation enteritis requiring surgical treatment due to failure of conservative management.RESULTS:IRI was located in the terminal ileum in 12 patients,in the rectum in 2 patients,in the descending colon in 2 patients,and in the cecum in one patient.All patients had resection of the affected region(s).There were no postoperative deaths,while 3 cases presented with postoperative complications (17.7%).All patients remained free of symptoms without evidence of recurrence of IRI for a median follow-up period of 42 mo (range,6-96 mo).CONCLUSION:We report a favorable outcome without IRI recurrence of 17 patients treated by resection of the diseased bowel segment.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第35期4013-4016,共4页 世界胃肠病学杂志(英文版)
基金 Supported by The University Hospital of Larissa
关键词 Pelvic neoplasms BOWEL Radiation injuries SURGERY 辐射损伤 有效管理 手术切除 肠道 效益 手术治疗 IRI 恶性肿瘤
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  • 1Waddell BE, Rodriguez-Bigas MA, Lee RJ, Weber TK, Petrelli NJ. Prevention of chronic radiation enteritis. J Am Coll Surg 1999; 189:611-624.
  • 2Gunnlaugsson A, Kjell6n E, Nilsson P, Bendahl PO, Willner J, Johnsson A. Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer. Acta Oncol 2007; 46:937-944.
  • 3Browning GG, Varma JS, Smith AN, Small WP, Duncan W. Late results of mucosal proctectomy and colo-anal sleeve anastomosis for chronic irradiation rectal injury. Br J Surg 1987; 74:31-34.
  • 4Allen-Mersh TG, Wilson EJ, Hope-Stone HF, Mann CV. The management of late radiation-induced rectal injury after treatment of carcinoma of the uterus. Surg Gynecol Obstet 1987; 164:521-524.
  • 5Harling H, Balslev L Surgical treatment of radiation injury to the rectosigmoid. Acta Chir Scand 1986; 152:691-693.
  • 6Anseline PF, Lavery IC, Fazio VW, Jagelman DG, WeaRley FL. Radiation injury of the rectum: evaluation of surgical treatment. Ann Surg 1981; 194:716-724.
  • 7Yeoh E. Radiotherapy: long-term effects on gastrointestinal function. Curr Opin Support Palliat Care 2008; 2:40-44.
  • 8Turina M, Mulhall AM, Mahid SS, Yashar C, Galandiuk S. Frequency and surgical management of chronic complications related to pelvic radiation. Arch Surg 2008; 143: 46-52; discussion 52.
  • 9Berthrong M, Fajardo LF. Radiation injury in surgical pathology: II Alimentary tract. Am J Patho11981; 5:581.
  • 10Gami B, Harrington K, Blake P, Dearnaley D, Tait D, Davies J, Norman AR, Andreyev HJ. How patients manage gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther 2003; 18:987-994.

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