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IGF-ⅠR在鼻息肉组织中的表达与变应性因素的关系 被引量：3

The expression and significance of IGF-ⅠR in nasal polyp and its relationship with allergic rhinitis
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摘要 目的:探讨胰岛素样生长因子-1受体(IGF-ⅠR)在鼻息肉组织中的表达及其与变应性因素的关系。方法:使用荧光定量PCR技术和免疫组织化学技术分别检测40例伴鼻息肉的慢性鼻-鼻窦炎患者的鼻息肉组织(CRSWNP组)和20例鼻中隔偏曲患者的中鼻甲组织(对照组)中IGF-ⅠR mRNA及其蛋白的表达并进行统计学分析。结果:IGF-ⅠR蛋白在CRSWNP组及对照组的阳性率分别为70.8%和12.3%,IGF-ⅠR mRNA在2组的表达分别为0.748±0.111和0.107±0.208,CRSWNP组IGF-ⅠR蛋白和IGF-ⅠR mRNA的表达均显著高于对照组(均P<0.01);CRSWNP组中,有、无鼻内镜手术史和有、无合并变应性因素组间的IGF-ⅠR mRNA表达均差异无统计学意义(均P>0.05)。结论:IGF-ⅠR在CRSWNP的发病机制中发挥作用,变应性因素不是IGF-ⅠR的表达的直接影响因素。 Objective：To study the expression of insulin-like growth factor-1 receptor（IGF-ⅠR） in nasal polyps and its relationship with allergic rhinitis.Method：The mRNA and protein expression of IGF-ⅠR in 40 cases（20 cases with allergic rhinitis and 20 cases without） nasal polyps tissue（the CRSWNP group） and 20 middle turbinate tissue samples（the control group） were examined by fluorescence quantitative polymerase chain reaction（FQ-PCR） and immunohistochemistry.Result：The positive stainning rate of IGF-ⅠR protein of nasal polyps tissue is 70.8% and that of control is 12.3%,the expression of IGF-ⅠR mRNA of nasal polyp is 0.748±0.111,which is significant higher than that of the control group is 0.107±0.208（P0.01）.NO significant difference of the expression of IGF-ⅠR mRNA between with and without allergic rhinitis cases and between with and without endoscopy sinus surgery history cases in the CRSWNP group.Conclusion：The overexpression of IGF-ⅠR maybeplay important roles in the formation of nasal polyp.Hypersensitivity reaction type I mediated by IgE has no contribution to the overexpression of the IGF-ⅠR.
作者 何宁 梁建平 陈俊 周向阳 韦海明 周祥祯 王涛
机构地区 广西壮族自治区人民医院耳鼻咽喉头颈肿瘤科 广西壮族自治区人民医院耳鼻咽喉科 广西壮族自治区人民医院放射科 广西壮族自治区人民医院检验科 广西壮族自治区人民医院病理科
出处 《临床耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2011年第22期1019-1021,1024,共4页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金 广西壮族自治区科学基金项目(No:桂科青0728040)
关键词 慢性鼻窦炎 鼻息肉 胰岛素样生长因子-Ⅰ受体 变态反应 chronic rhinosinusities nasal polyp insulin-like growth factor-1 receptor hypersensitivity
分类号 R765.4 [医药卫生—耳鼻咽喉科]
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参考文献7

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同被引文献25

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二级引证文献9

临床耳鼻咽喉头颈外科杂志
2011年 第22期

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