早期未治疗帕金森病患者前瞻性记忆损害和事件相关电位改变的特点

Characteristics of prospective memory impairment and event-related potentials changes in Parkinson＇s disease patients without early treatment

目的探讨早期未治疗PD患者前瞻性记忆损害情况和事件相关电位（ERPs）改变的特点。方法选择自2007年1月至2010年10月在河南省人民医院神经内科门诊确诊的早期未治疗的PD患者33例（PD组）和同期该家医院31名健康体检者（健康对照组）进行研究，研究项目包括基于事件的前瞻性记忆（EBPM）、基于时间的前瞻性记忆（TBPM）和ERPs综合检查。结果PD组EBPM和TBPM评分均明显低于对照组，差异均有统计学意义（P〈0．05）；PD组N2、P300潜伏期均较健康对照组明显延长，P300波幅与对照组比较明显降低，差异均有统计学意义（P〈0．05）。相关分析结果显示，PD患者的P300潜伏期与EBPM和TBPM均呈明显正相关，r值分别为0．628、0．582，P值均为0．000。结论早期未治疗PD患者存在EBPM和TBPM损害：P300潜伏期可作为判定PD患者EBPM和TBPM损害程度的电生理指标。

Objective To investigate the characteristics of prospective memory impairment and event related potentials （ERPs） changes in Parkinson＇ s disease （PD） patients without early treatment. Methods Event-based prospective memory （EBPM）, time-based prospective memory （TBPM） and ERPs were examined in 33 PD patients and 31 healthy controls matched with age, gender, education and occupation. Results The scores of EBPM and TBPM in PD patients were significantly lower than those in normal controls （P〈0.05）. The latencies of N2 and P300 were significantly prolonged, and P300 amplitude was markedly decreased in PD patients as compared with those in normal controls （P〈0.05）. The relative analysis showed that the P300 latency was positively correlated with both EBPM （r=0.628, P=0.000） and TBPM （r=0.582, P=0.000）. Conclusion The EBPM and TBPM impairment might exist in PD patients without early treatment; the P300 latency can be used as a predictive electrophysiological marker to assess the severity of EBPM and TBPM impairment in PD patients.