帕金森病患者便秘相关因素分析

Correlative factors of constipation in patients with Parkinson＇s disease

目的探讨PD患者便秘的相关因素。方法选取PD患者212例，采用便秘量表评定PD患者的便秘程度，详细记录患者的年龄、病程、用药情况，并进行UPDRSDI评分、Hoehn—Yahr分期、汉密顿抑郁量表（HAMD）评分、中文版简易智能精神状态检查量表（MMSE）评分，将各项因素与便秘进行偏相关分析，并利用二分类Logistic回归分析筛选PD患者合并便秘的危险因素。结果212例PD患者的年龄、Hoehn．Yahr分期、HAMD总分与便秘有显著的相关关系（P〈0．05），是便秘的危险因素，而性别、病程、盐酸苯海索每日剂量、吡呗地尔每日剂量、左旋多巴每日剂量、UPDRSⅢ评分、MMSE总分与便秘无显著的相关关系（P〉0．05）。结论PD患者便秘与年龄、Hoehn—Yahr分期、HAMD总分有关。

Objective To investigate the correlative factors of constipation in patients with Parkinson＇s disease （PD）. Methods Two hundred and twelve patients with PD were enrolled in our study. Constipation scale was used to evaluate the degree of constipation. The data of patient＇s age, course of disease and medication were collected; UPDRS Ⅲ scale, Hoehn-Yahr scale, Hamilton Depression Rating Scale （HAMD）, Chinese version of mini mental state examination （MMSE） were performed; risk factors of constipation in patients with PD were analyzed by partial correlation and binary-logistic regression. Results The age, Hoehn-Yahr stage, HAMD scores in 212 patients with PD were significantly associated with constipation （P〈0.05） and were the risk factors for constipation. However, gender, course of disease, paralest daily dose, piribedil sustained daily dose, levodopa daily dose, UPDRS Ⅲ scores and MMSE scores were not significantly correlated to constipation （P〉0.05）. Conclusion Age, Hoehn-Yahr stage and HAMD scores have correlation with constipation in patients with PD.