多糖调控巨噬细胞免疫应答机制的研究进展

Immunostimulating Mechanisms of Polysaccharides on Macrophages

多糖是一类来源广泛且具有多种生物学活性的天然大分子物质,能增强机体先天性和适应性免疫系统。近来研究发现,生物活性多糖能通过巨噬细胞表面多种受体诱导复杂而又交叉的信号转导,调控细胞功能和相关细胞因子的表达,但对于相关的研究缺乏系统的归纳分析。该文综述了生物多糖对巨噬细胞的免疫调节作用、刺激信号通路以及多糖结构与受体关系,旨在为相关领域的研究提供参考。

As widely distributed natural macromolecules, polysaccharides exhibit a number of biologic activities, especially immunopromoting effects on immune system. Bioactive polysaccharides can stimulate multiple signaling pathways via macrophage receptors followed by improving the secretion of cytokines, and finally enhance the cellular immune function. The present review focuses on the immunostimulating effects, potential mechanisms and structure-receptor relationship of polysaccharides on macrophages, which purposes to provide the basic information ofpolysaccharide-induced macrophage activation for related researches.