宫颈微腺体增生7例临床病理分析

Cervical microglandular hyperplasia: clinical and pathological analysis of 7 cases

[目的]探讨宫颈微腺体增生病理组织学特征、诊断标准及鉴别诊断。[方法]采用常规HE染色确定病理诊断的基础上采用免疫组化Envision二步法分析7例宫颈微腺体增生,并结合文献进行临床病理分析。[结果]7例宫颈微腺体增生患者平均年龄41.6岁,其中3例有口服避孕药史;1例病理组织学显示宫颈微腺体增生伴不典型增生。免疫组化显示增生腺体对CEA、P53、Ki-67、P16均不表达。[结论]宫颈微腺体增生属于一种良性宫颈病变,大多数光镜下可明确诊断。对于不典型宫颈微腺体增生,需依靠病理组织形态学特征和免疫组化标记进行诊断。

[ Objective] To investigate cervical micro gland hyperplasia istopathological characteristics, diagnostic criteria and differential diagnosis. [ Methods] Conventional HE staining and immunohistochemical envision two step analysis of 7 cases of cervical micro gland hyperplasia were used. [ Results I Seven cases,in the average age of 41.6 years old,presented cervical micro gland hyperplasia. Three of them had a history of oral contraceptive use and 1 case of the cervical micro gland hyperplasia showed atypical hyperplasia. Immunohistochemistry test indicated that the CEA, P53, Ki -67, P16 were not expressed in hyperplastic glands.[ Conclusion] Cervical micro gland hyperplasia is a completely benign cervical lesions. Its diagnosis cam be made under light microscope. For the atypical cervical micro gland hyperplasia, the diagnosis depends on the pathologic morphology and immunohisto - chemical markers.