IgA肾病的发病机制研究进展

Pathogenesis of IgA Nephropathy

IgA肾病(IgA nephropathy,IgAN)是以IgA或IgA为主的免疫球蛋白弥漫沉积在肾小球系膜区及毛细血管袢,临床表现和病理改变各异的临床-病理综合征。目前认为在广泛应用肾活检技术的国家,本病是最常见的慢性肾小球疾病,也是引起终末期肾病(end-stage renaldisease,ESRD)的主要病因之一。迄今为止,IgA肾病的发病机制尚不十分清楚。本文就目前IgA肾病发病的现代医学研究的进展进行综述。

IgA nephropathy （IgAN） refers to the clinicalpathological syndrome of different clinical symptoms and pathological changes that result from the dispersed deposition of IgA or IgA - dominant immunoglobulins on the glomerular mesangium and the capillary loop. Currently it is viewed as the most common chronic glomerular disease in those countries where renal biopsy is wildly used. IgA nephropathy also is one of the most widely observed primary glomerular diseases and is the major cause of end - stage renal disease. Although so much research about this has been taken, the etiopathogenisis of IgAN is not yet clear. This article will review contemporary information concerning the possible pathogenetic mechanisms involved in IgA nephropathy.