艾普拉唑治疗十二指肠溃疡的Meta分析

llaprazole in the treatment of duodenal ulcer：a Meta analysis

目的采用Meta分析的方法系统评价新型质子泵抑制剂艾普拉唑对十二指肠溃疡的疗效。方法检索比较艾普拉唑和其他质子泵抑制剂治疗十二指肠溃疡的随机对照临床试验，进行荟萃分析。结果共有6篇文献符合入选标准，共纳入1319例十二指肠溃疡患者。荟萃分析显示10mg/d艾普拉唑4周溃疡愈合率为89．1％（591／663），略高于对照组的86．4％（426／493），但差异无统计学意义（P〉0．05）。进一步对高质量文献、中文文献、英文文献和以奥美拉唑为对照药物行敏感性分析，结果差异均无统计学意义（P〉0．05）。此外，10mg/d艾普拉唑不良反应率为9．7％（64／663），对照组为12．6％（62／493），两组比较差异也无统计学意义（P〉0．05）。艾普拉唑5m删和10mg／d治疗4周溃疡愈合率分别为84．7％（138／163）、84．0％（131／156），两者比较差异无统计学意义（P〉0．05）。结论艾普拉唑治疗十二指肠溃疡有较高的愈合率，并且耐受性良好，5mg，d的疗效与10mg，d基本相当。

Objective To systematically review the efficacy of ilaprazole in duodenal ulcer by Meta analysis. Methods Randomized controlled trial （RCT） comparing ilaprazole with other proton pump inhibitors in duodenal ulcer were searched for Meta analysis. Results Six RCT met the inclusion criteria and 1319 patients were included. Meta analysis showed that the healing rate at 4-week in the dose of ilaprazole 10 mg/d was higher than that in control group [ 89.1% （591/663 ） vs. 86.4% （426/493） ], but there was no significant difference （P 〉 0.05 ）. When including high-quality literature, English literature, Chinese literature, or the literature using omeprazole as control, there was no significant difference either （P 〉 0.05 ）. The adverse rate in the two groups had no significant difference [9.7%（64/663 ） vs. 12.6%（62/493）] （P 〉 0.05）. The 4-week healing rate between the doses of ilaprazole 5 mg/d and 10 mg/d had no significant difference [84.7%（138/163） vs. 84.0%（131/156）]（P〉0.05）. Conclusions Ilaprazole has high healing rate for duodenal ulcer, with low adverse rate. The effect of the dose of 5 mg/d is comparable to 10 mg/d.