围术期使用普瑞巴林预防与缓解腹腔镜下胆囊切除术后肩痛的疗效评估

腹腔镜术后肩（postlaparoscopicshoulderpain，PLSP）经常发生于腹腔镜手术后。本文采用安慰剂对照研究，试验组患者在围手术期间相隔124、时分2次予总量为300mg的普瑞巴林，综合评估了普瑞巴林对于预防与缓解腹腔镜胆囊切除术后PLSP的疗效、PLSP的发生频率和严重程度、术后补偿止痛需求以及术后48小时内的药物副作用。结论显示两组PLSP的发生率无显著差别，且各时间，点的PLSP疼痛评分、初次使用补偿止痛的时间以及累积酮洛酸氨丁三醇用量也相同。然而普瑞巴林组术后2小时的过度镇静作用的发生率要高于安慰剂组。

Postlaparoscopic shoulder pain （PLSP） frequently follows laparoscopic surgery. In this placebo-controlled study, we evaluated the efficacy of two perioperative doses of pregabalin 300 mg 12 h apart for preventing and attenuating PLSP after laparoscopic cholecystectomy. The frequency and severity of PLSP, need for postoperative rescue analgesia, and side effect profiles were assessed for 48 h postoperatively. In both groups, the overall incidence of PLSP did not differ significantly, and the pain score for PLSP, time to first rescue analgesia, and cumulative ketorolac consumption were similar at each fimepoint. However.the 2-h postoperative incidence of oversedation was higher with pregabalin.