5小时口服葡萄糖耐量试验在诊断餐后低血糖中的应用

The application of 5 hours oral glucose tolerance test in diagnosising postprandial hypoglycemia

目的在有或无疑似餐后低血糖症状的受试者中进行5小时口服葡萄糖耐量试验(5hOGTT),探讨OGTT特征及其临床应用价值。方法共纳入27例有疑似餐后低血糖症状的受试者和41例无餐后低血糖症状的受试者,均行82.5g葡萄糖的5hOGTT。结果在无餐后低血糖症状的受试者中共筛查出低血糖6例。在有疑似餐后低血糖的受试者中共筛查出低血糖17例,低血糖再现率83%。诊断服糖后低血糖的人群中IGT伴发率达30%。结论与无餐后低血糖症状人群相比,有疑似餐后低血糖人群中服糖后低血糖的发生率高达63%,服糖后低血糖病例的IGT伴发率达29%。对有疑似餐后低血糖病例进行4hOGTT低血糖筛查敏感性达100%。

Objective To discuss the characteristics and clinical value of OGTT, 5-h OGTT was carried out in subjects with or without suspected postprandial hypoglycemia symptoms. Methods 27 subjects with suspected postprandial hypoglycemia symptoms and 41 subjects without postprandial hypoglycemia symptoms accepted 82.5g 5-h OGTT. Results In group without postprandial hypoglycemia symptoms, 6 cases hypoglycemia were detected. In group with suspected postprandial hypoglycemia symptoms, 17 cases hypoglycemia were detected. The reappearance rate of hypoglycemia was 83%. In all hypoglycemia cases, the incidence of IGT reached 30%. Conclusion As compared to the group without postprandial hypoglycemia symptoms, the incidence of hypoglycemia in the group with suspected post-prandial hypoglycemia symptoms is higher, reaching 63%. At the same time, the incidence of IGT reaches 29% . In patients with suspected postprandial hypoglycemia symptoms, the sensitivity of detecting hypoglycemia reaches 100% by 4-h OGTT.