摘要
采用硼氢化钠/氯化钙还原体系将乙酰基二茂铁还原为1-二茂铁基乙醇。探讨了硼氢化钠、氯化钙的用量及反应时间对还原产物收率的影响,得到了乙酰基二茂铁还原的优化条件:投料比n(FcCOCH3)∶n(NaBH4)∶n(CaCl2)=1∶3∶2,以甲醇为溶剂,在碱性条件下回流1.5 h。在此条件下,1-二茂铁基乙醇的收率达87.5%。利用IR、1H NMR和元素分析对产物进行了结构确证。
Acetyl ferrocene can be reduced to 1-（ferrocenyl）ethanol by NaBHJCaC12. The effects of molar ratio of materials, reaction time and reaction temperature were investigated. Under optimized conditions, the target product was obtained in 87.5% yield in methanol under reflux. The structure of 1-（ferrocenyl） ethanol was identified by ＇H NMR, IR and elemental analysis.
出处
《精细化工中间体》
CAS
2011年第5期70-72,共3页
Fine Chemical Intermediates
基金
贵州省教育厅青年项目(20070085)
毕节地区科技局计划项目资助(2007046)
