非那雄胺对大体积前列腺增生组织微血管密度的影响

Effect of finasteride on microvascular density in BPH patients with large-volume prostate

目的评价术前服用不同疗程非那雄胺对大体积前列腺(>80mL)经尿道前列腺电切除术(TURP)术中出血的影响,以及对前列腺组织中微血管密度(MVD)的影响。方法 166例大体积良性前列腺增生症(BPH)患者,对于术前服用非那雄胺5mg/d,1周的40例患者为A组;服用5mg/d,2周的45例患者为B组;服用5mg/d,4周的38例患者为C组;术前未服用非那雄胺的43例患者为对照组,记录TURP前列腺切除质量,计算术中失血量,免疫组织化学方法检测前列腺组织MVD。结果 A组、B组与对照组术中出血量、平均切除1g前列腺组织失血量,前列腺MVD差异无统计学意义(P>0.05);C组术中出血量、平均切除1g前列腺组织失血量,前列腺MVD小于对照组,差异有统计学意义(P<0.05)。结论对于大体积前列腺,术前应用非那雄胺4周方可减少TURP术中出血,减少腺体内MVD。

Objective To evaluate preoperative finasteride on decreasing operative bleeding during TURP with prostate size greater than 80 mL,and to study its mechanism.Methods Totally 166 patients with benign prostatic hyperplasia（BPH） with prostate size greater than 80 mL were scheduled for TURP;before surgery,40 of them were received 5 mg of finasteride daily for one week（A group）,45 of them were received 5 mg of finasteride for two weeks（B group）,38 of them were received 5 mg of finasteride for four weeks（C group）,the other 43 patients were not received finasteride（control group）.A comparative study of clinical data was made among the four groups.Results The operation was successfully completed in 166 cases.Intraoperative blood loss,blood loss of 1 gram prostate tissue for resection,the expression of microvascular density in the groups A,B,control were no statistical significance difference（P0.05）,whereas there were statistically significant difference between the groups C and control（P0.05）.Conclusion For BPH patients with large-volume prostate,the use of finasteride before TURP for 4 weeks can reduce perioperative bleeding.