丁酸氢化可的松乳膏在面部脂溢性皮炎中的疗效观察

The observation of efficacy for hydrocortisone butyrate cream in facial seborrheic dermatitis

目的探讨丁酸氢化可的松乳膏治疗面部脂溢性皮炎的疗效及安全性。方法选取2007年6月～2009年6月,我科收治的124例面部脂溢性皮炎患者,作为研究对象。按照治疗方法的不同,将所有患者随机分为丁酸氢化可的松组(A组)、氟芬那酸丁酯组(B组)、丁酸氢化可的松组联合氟芬那酸丁酯组(C组)。比较三组患者用药后2周、3周、4周的症状改善情况并评定疗效,随访3个月后的复发率,统计治疗过程及随访过程中的不良反应,综合评价丁酸氢化可的松乳膏治疗面部脂溢性皮炎的临床效果健全性。结果经研究显示,A组和C组患者用药后2周、3周、4周患处症状改善情况明显优于B组患者,4周后总有效率比较A、C组较B组明显高,上述比较差异均有显著性,P值均<0.05,均具有统计学意义;A、C组总有效率无显著性差异;3月随访复发率比较,B、C组复发率明显低于A组,比较有显著性差异,B、C组间无明显差异;两组患者用药后不良反应主要有皮肤灼烧感,发生率无显著性差异。结论丁酸氢化可的松乳膏治疗面部脂溢性皮炎具有起效快、疗效确切、不良反应小的优点,和氟芬那酸丁酯软膏联合应用,可明显增强其疗效,降低复发率。

Objective To investigate the efficacy and security for hydrocortisone butyrate cream in facial seborrheic dermatitis.Methods 124 cases of facial seborrheic dermatitis patients treated in our department from June 2007 to June 2009 were chosen as the research object.According to different methods of treatment,all patients were randomly divided into butyrate hydrocortisone group（A）,fluorine fun that butyl acrylate group（B）,hydrocortisone butyrate group that combined fun butyl fluoride group（C group）.The symptom improvement and assessment of efficacy 2 weeks,3 weeks,4 weeks after treatment for the three groups of patients were compared.The recurrence rate after 3 months was followed-up.The adverse reactions of treatment and during follow-up were taken for statistics.Evaluate comprehensively the clinical effects and integrity for hydrocortisone butyrate cream in treatment of facial seborrheic dermatitis.Results The study showed that the lesion symptom improvement 2 weeks,3 weeks,4 weeks after treatment for patients of A and C was significantly better than B group.The total effective rate after 4 weeks for A,C group was significantly higher than in group B,the differences were significant（P0.05）.There was statistically significant.There was no significant difference in efficiency for A,C group.The follow-up relapse rate for 3 months was compared,the relapse rate for B,C group was significantly lower than in group A,there was a significant difference.There was no significant difference between B,C groups.The adverse reactions for two groups of patients after treatment were skin burning sensation.And the incidence was no significant difference.Conclusions There are apid onset of efficacy and few side effects benefits for hydrocortisone butyrate cream in treatment of facial seborrheic dermatitis,that combined with acid ester ointment fluoride can significantly enhance its efficacy,and reduce lower recurrence rate.