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Wnt5a与肿瘤的研究进展 被引量：4

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摘要 Wnt信号通路参与成体细胞增殖、分化和凋亡过程。信号转导通路包括经典的Wnt通路和非经典Wnt/JNK通路及Wnt/Ca2+通路等。信号转导通路出现异常导致肿瘤生成。Wnt基因最初是在小鼠的乳腺癌中发现的,目前在哺乳动物中已发现19个Wnt家族。其中Wnt5a主要介导非经典Wnt/Ca2+通路,但也可以激活经典Wnt通路。Wnt5a的多种肿瘤中出现表达增高、降低或缺失。本文旨从Wnt5a的两面性、Wnt信号通路的调节和Wnt5a与肿瘤的关系三个方面进行综述。
作者 赵丽 周英琼
机构地区 桂林医学院附属医院病理科
出处 《齐齐哈尔医学院学报》 2011年第19期3168-3172,共5页 Journal of Qiqihar Medical University
关键词 WNT5A 信号通路 肿瘤 调节
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献57

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二级参考文献7

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共引文献35

同被引文献29

引证文献4

二级引证文献15

齐齐哈尔医学院学报
2011年 第19期

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