急性脑梗死患者血清同型半胱氨酸、高敏C反应蛋白及D-二聚体水平的变化

Serum Homocysteine,High Sensitivity C-reactive Protein and D-dimer Levels in Acute Cerebral Infarction

目的探讨急性脑梗死患者同型半胱氨酸、高敏C反应蛋白及D-二聚体水平的变化及临床意义。方法 2008年6月～2010年6月在我院收治的急性脑梗死患者110例,设立为梗死组,另选择同期我院健康体检者100例设为健康对照组,分别比较分析两组不同病灶及不同程度的Hcy、hs-CRP、DD的含量。其中Hcy、hs-CRP采用日本东芝TBA-40全自动生化分析仪检测。D-二聚体检测采用双抗体夹心法检测。结果①急性脑梗死组的110例患者血清中Hcy、hs-CRP、DD的含量均明显高于健康对照组,两组上述指标分别比较,差异有统计学意义(P<0.05或P<0.01)。②大梗死病灶患者的Hcy、hs-CRP、DD的含量明显高于中小梗死病灶的含量(P<0.05)。③重度梗死病灶患者的Hcy、hs-CRP、DD的含量明显高于轻度、中度梗死病灶的含量(P<0.05)。结论急性脑梗死的发生、发展与Hcy、hs-CRP、D-二聚体关系密切,上述各指标将逐渐成为临床诊断急性脑梗死的常规检测指标,对脑梗死患者进行上述各指标的检测,能够为临床治疗提供可靠依据,从而起到重要的预防作用。

Objective To evaluate homocysteine in patients with acute cerebral infarction, high-sensitivity C-reactive protein and D-dimer levels and the clinical significance. Methods From June 2008 to June 2010 in our hospital 1 l0 patients with acute cerebral infarction, established as infarction, another healthy choice in our hospital over the same period were 100 cases set to the healthy control group, respectively, a comparative analysis of two different lesions and different levels of Hcy, hs-CRP, DD levels. Which Hey, hs-CRP with Japanese Toshiba TBA-40 automatic biochemical analyzer. D-dimer were detected by double-antibody sandwich assay. Results （j） acute cerebral infarction, 110 patients with serum Hcy, hs-CRP, DD levels were significantly higher than the control group, two sets of these indicators, respectively, the difference was statistically significant （ P 〈 0.05 or P 〈 0.01 ）. （~ Large infarct lesion in patients with Hcy, hs-CRP, DD were significantly higher than the content of small infarction lesions, the difference was statistically significant. （~ Lesions in patients with severe infarction Hcy, hs-CRP, DD were significantly higher than the mild, moderate levels of infarct lesion, the difference was statistically significant. Conclusion The incidence of acute cerebral infarction, development and Hcy, hs-CRP, D-dimer are closely related, the above indicators will gradually become a routine clinical diagnostic test indicator of acute cerebral infarction, cerebral infarction in patients with above target detection to provide a reliable basis for clinical treatment, which play an important role in prevention.