慢性HBV携带者血清胆汁酸和前白蛋白检测的临床意义

The Clinical Significance of Testing the Serum Bile Acid and Prealbumin of Chronic HBV Carriers

目的探讨慢性HBV携带者血清胆汁酸(TBA)、前白蛋白(PA)测定的临床意义。方法分别检测152例慢性HBV携带者(观察组)及150例健康体检者(对照组)的血清胆汁酸、前白蛋白水平并进行分析。结果观察组血清TBA、PA异常检出率明显增高,与正常对照组比较差异显著(均P<0.01);观察组血清TBA水平(19.78±7.24)μmol/L,PA水平(178.30±59.25)mg/L;对照组TBA水平(5.02±3.03)μmol/L,PA水平(291.80±29.35)mg/L,两组比较差异显著(均P<0.01)。结论联合检测慢性HBV携带者血清TBA和PA有助于发现肝脏合成及代谢功能的早期损害。

Objective To study the clinical significance of testing serum bile acid （ TBA ） and prealbumin （ PA ） of the chronic HBV carriers. Methods The serum levels of bile acid and prealbumin in 152 cases of chronic HBV carriers （ the observation group ） and 150 cases of the physical examination （ control group ） were respectively detected and analyzed. Results The levels of TBA and PA in the observation group were higher than those in the normal control group, and the differences were statistically significant （ P 〈 0.01 ） ; The levels of TBA, PA were （ 19.78 ± 7.24 ） μmol/L and （ 178.30 ± 59.25 ） μmol/L in the observation group, and the levels of TBA, PA were （ 5.02 ± 3.03 ） μmol/L and （ 291.80 ± 29.35 ） μmol/L in the control group, and the differences between the two groups were statistically significant （P 〈 0.01 ）. Conclusion Joint detection of TBA and PA in serum of chronic HBV carriers can help to find the early damage to the liver metabolism.