摘要
目的观察多西他赛联合替吉奥(S-1)治疗晚期胃癌的疗效及毒副反应。方法 50例胃癌晚期患者接受多西他赛75mg/m2静脉滴注,第一天;替吉奥80mg/m2,2次/d,口服2周,21d为1个周期,连续用药2个周期以上评价疗效及毒副反应。结果在可评价疗效的50例患者中,CR 3例,PR 25例,SD 13例,PD 9例,RR为56%。主要不良反应是骨髓抑制和胃肠道反应。结论多西他赛联合S-1治疗晚期胃癌具有较好的疗效,不良反应可耐受,是晚期胃癌化疗的有效方案。
Objective To evaluate the efficacy and adverse effects of combination of docetaxel and S-1 in treatment of advanced gastric cancer. Methods All 50 patients with advanced gastric cancer were treated with docetaxel 75mg/m2 the 1st day and S1 80mg/ m2 （ in two divided oral doses ）. The chemotherapy repeated every 3 weeks. Efficacy and adverse effects were reviewed after more than 2 cycles of chemotherapy （ 1 cycle=21days ）. Results Among 50 evaluable patients, 3 cases showed complete remission,25 cases partial remission, 13 cases stable and 9 cases disease progression, and the overall response rate was 56%. The main adverse reactions were myelosuppression, nausea and vomiting. Conclusion The combination of docetaxel and SI is well tolerated and effective in the treatment of advanced gastric cancer.
出处
《中国现代医生》
2011年第32期147-148,共2页
China Modern Doctor
关键词
胃癌
化学疗法
多西他赛
Gastric cancer
Chemotherapy
Docetaxel
