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蛋白激酶Cα结构及其组织分布 被引量：1

The structure and tissue distribution of protein kinase Cα
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摘要 蛋白激酶C（protein kinase C,PKC）是1977年在鼠脑的胞质成分中发现的一种依赖磷脂和钙的蛋白激酶,是细胞信号转导途径中重要的物质。PKC由多种具有不同生物学特性的同工酶组成,不同的PKC同工酶有着不同的酶学特性,在组织中的表达不同,在细胞信号传递中的作用也有着显著差别。近年来由对PKC整体功能的探索逐步转向到对PKC家族成员进行分别研究。本文就PKCα这种亚型的结构及其在正常组织和肿瘤组织的分布作一综述。
作者 董瓅瑾 赵艳威 杨彩凤 尹行志 秦琴 宋光明
机构地区 武警后勤学院 武警后勤学院附属医院 青海省第五人民医院急诊 解放军
出处 《武警医学院学报》 CAS 2011年第11期918-921,共4页 Acta Academiae Medicinae CPAPF
基金 武警后勤学院院级课题(WY2006-1)
关键词 蛋白激酶CΑ 结构 组织分布
分类号 R393 [医药卫生—基础医学]
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参考文献37

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二级参考文献15

  • 1Sun, Q. Y., Y. Lax, S. Rubinstein, D. Y. Chen &H. Breitbart, 1999, Mitogen-activated protein kinase and cell cycle progression during mouse egg activation induced by various stimuli. Z. Natursfoesch [ c ], 54:285 - 294.
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  • 8Sun, Q. Y., S. Rubinstein & H. Breitbart, 1999,MAP kinase activity is down-regulated by phorbol ester during mouse oocyte maturation and egg fertilization.Mol, Reprod. Dev., 52: 1-9.
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  • 10Moscat, J. & M. Diaz-Meco, 2000, The atypical protein kinase Cs. EMBO Reports, 1 : 399 - 403.

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武警医学院学报
2011年 第11期

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