二甲双胍治疗不同糖代谢状态肥胖儿童效果评价

Effects of metformin therapy on obese children in their different glucose metabolism status

【目的】比较单纯生活方式和加用二甲双胍对肥胖儿童血糖血脂相关指标治疗效果【方法】肥胖儿童101例根据OGTT分为组1,糖代谢正常高胰岛素血症组50例,组2,糖代谢异常组51例。组1A单纯生活方式治疗,组1B和组2二甲双胍加生活方式干预治疗1年。【结果】组1A治疗前后的体重指数,糖代谢指数,血脂,没有明显的改善(P>0.05)。组1B及组2治疗前后的体重指数,糖代谢指数,血脂,有明显的改善(P<0.01)。【结论】二甲双胍加用生活方式的干预优于单纯生活方式的干预。

[Objective] To compare the 12 months effect of metformin treatment on obese children. [Methods] 101 ohese children were grouped base on OGTT, Group 1 were 50 with hyperinsulinemia cases, among of them, 20 cases （Group IA） managed by lifestyle interferering and other 30 cases （Group 1B） treated with metformin. Group 2 were 51 IGR/T2DM cases treated with metformin and lifestyle interfering. [Results] Group 1A before and after treatment of the body mass index, index of glucose metabolism, blood lipids, had no significant improvement （P〉 0.05）. Group 1B and group 2 before and after treatment of the body mass index, index of glucose metabolism, blood lipids, were improved signifi- eantly,（P（0.01）. [Conclusion] Metformin combined with life-style is better than lifestyle alone.