左氧氟沙星致血小板减少症

Levofloxacin-induced thrombocytopenia

1例74岁男性患者,因胸腔积液和慢性阻塞性肺疾病给予左氧氟沙星0.3 g,1次/d静脉滴注,贞芪扶正胶囊6粒,2次/d口服。用药前血小板计数108×109/L,用药13 d时降为10×109/L,14 d降至7×109/L。立即停用左氧氟沙星和贞芪扶正胶囊,改为头孢美唑钠2.0 g、2次/d静脉滴注,小牛脾提取物10 ml、1次/d静脉滴注,盐酸小檗胺112 mg、3次/d口服,并连续3 d输注血小板。治疗12 d后患者血小板水平恢复至105×109/L。

A 74-year-old man received an IV infusion of levofloxacin 0.3 g once daily and 6 Zhenqifuzheng capsules twice daily for hydrothorax and chronic obstructive pulmonary diseases. His platelet count was 108×10^9/L before treatment and, on days 13 and 14 after drug administration, his platelet count dropped to 10×10^9/L and 7 ×10^9/L, respectively. Levofloxacin and Zhenqifuzheng capsules were withdrawn. He received platelet transfusions for three days, IV infusions of cefmetazole sodium 2.0 g twice daily, calf spleen extractive injection 10 ml once daily, and oral berbamine hydrochloride 112 mg 3 times a day. Twelve days later, his platelet count returned to 105×10^9/L.