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Gene Expression Changes in the Pituitary Gland of Rats Exposed to Electromagnetic Pulses 被引量：1

Gene Expression Changes in the Pituitary Gland of Rats Exposed to Electromagnetic Pulses
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摘要 Objective We examined alterations in the expression of tumorigenesis‐related genes in the pituitary gland of rats exposed to electromagnetic pulses （EMP）.Methods The global gene expression profiles of the pituitary gland in EMP‐exposed and control groups were detected by cDNA microarray analysis.We then validated and further investigated the reduced expression of two tumorigenesis‐related genes,Pten,and Jund,by assessing their mRNA and protein expression by quantitative real‐time‐PCR,western blotting,and immunohistochemistry in the pituitary gland of rats 6 months after exposure to EMP.Results EMP exposure induced genome‐wide gene expression changes in the rat pituitary gland.There was decreased expression of the Pten and Jund mRNAs and proteins in EMP‐exposed rats compared with in unexposed control animals.Conclusion EMP exposure alters the expression of tumorigenesis‐related genes in the pituitary gland.These tumorigenesis‐related genes are potentially involved in the development of pituitary gland tumors in rats. Objective We examined alterations in the expression of tumorigenesis‐related genes in the pituitary gland of rats exposed to electromagnetic pulses （EMP）.Methods The global gene expression profiles of the pituitary gland in EMP‐exposed and control groups were detected by cDNA microarray analysis.We then validated and further investigated the reduced expression of two tumorigenesis‐related genes,Pten,and Jund,by assessing their mRNA and protein expression by quantitative real‐time‐PCR,western blotting,and immunohistochemistry in the pituitary gland of rats 6 months after exposure to EMP.Results EMP exposure induced genome‐wide gene expression changes in the rat pituitary gland.There was decreased expression of the Pten and Jund mRNAs and proteins in EMP‐exposed rats compared with in unexposed control animals.Conclusion EMP exposure alters the expression of tumorigenesis‐related genes in the pituitary gland.These tumorigenesis‐related genes are potentially involved in the development of pituitary gland tumors in rats.
作者 QI YuHong LIANG Jun HIM YanPing DING GuiRong LIU JunYe SU XiaoMing GUO GuoZhen
机构地区 Department of Radiotherapy Department of Radiotion Medicine Department of Pathology
出处 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第5期560-568,共9页 生物医学与环境科学（英文版）
基金 supported by the Research Fund of the National Natural Science Foundation of China (No: 60871068 30970670)
关键词 TUMORIGENESIS Electromagnetic pulses Pituitary gland PTEN JUND Tumorigenesis Electromagnetic pulses Pituitary gland Pten Jund
分类号 Q78 [生物学—分子生物学] TU895 [建筑科学]
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Biomedical and Environmental Sciences
2011年 第5期

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