摘要
The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.
The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.
基金
Supported by the National Natural Science Foundation of China(Nos.2007CB914403, 50803029)
the Natural Science Foundation of Tianjin City, China(No.10JCYBJC04100)
the Fundamental Research Funds for the Central Universities of China
