p504S和PCNA在前列腺癌中的表达及其意义

Expression and significance of p504S and PCNA in human prostatic carcinoma

目的:探讨前列腺癌及前列腺增生组织中p504S和PCNA的表达与临床意义。方法:采用免疫组织化学方法检测31例前列腺增生及59例前列腺癌患者p504S和PCNA的表达水平。结果:PCNA在前列腺癌组织中表达阳性率较前列腺良性增生组织中明显增加,差异极有统计学意义(P<0.01),PCNA的表达随着组织学分级及临床分期的增加而增加(P<0.05);p504S在前列腺癌组织中的表达阳性率明显高于在前列腺增生组织中的表达,差异极有统计学意义(P<0.01),其阳性强弱表达在各级前列腺癌组织中差异无统计学意义(P>0.05)。结论:p504S是前列腺癌敏感而特异性的标记物,p504S与PCNA联合检测,可以提高前列腺癌诊断的准确率。

Objective：To study the expressions of p504S and PCNA in prostatic carcinoma and benign prostatic hyperplasia（BPH） as well as their clinical significance.Methods：The expressions of p504S and PCNA in 31 cases of benign prostatic hyperplasia and 59 cases of prostatic carcinoma were detected by immunohistochemical methods.Results：The expression of PCNA in the carcinoma tissue was significant higher than that in the benign prostatic hyperplasia tissue,the difference was significant（P0.01）.The expression of PCNA was increased with the increase of pathological grade and clinical grade（P0.05）.The expression of p504S in the carcinoma tissue was significant higher than that in the benign prostatic hyperplasia tissue,the difference was significant（P0.01）.But which was not connected with pathological grade and clinical grade.Conclusion：p504s is a sensitive and specific prostate cancer marker.Combined detection of p504s and PCNA can greatly improve the diagnosis of prostatic cancer.