氨酚羟考酮片与盐酸羟考酮缓释片在晚期癌痛治疗的药物经济学分析

Pharmacoeconomic analysis of Oxycodone and Acetaminophen Tablets and Oxycodone Hydrochloride Prolonged-Release Tablets in treatment of advanced cancer pain

目的:比较氨酚羟考酮片(泰勒宁)与盐酸羟考酮缓释片(奥施康定)用于晚期癌痛患者镇痛治疗的成本-效果,为临床用药提供指导。方法:选取晚期癌痛患者148例,其中泰勒宁组73例,奥施康定组75例,比较用药4周后的镇痛疗效、不良反应及用药成本,运用药物经济学成本-效果分析法评价两组治疗方案。结果:泰勒宁组镇痛治疗总有效率为86.3%,奥施康定组为90.7%,两组间疗效差异无统计学意义(P>0.05),泰勒宁组的不良反应发生率较奥施康定组低。成本/效果比(C/E)泰勒宁组为1861,奥施康定组为2878。结论:泰勒宁和奥施康定用于晚期癌痛患者镇痛治疗疗效相当,泰勒宁治疗成本较低,奥施康定不良反应较高。

Objective：To assess the cost-effect ratio of Oxycodone and Acetaminophen Tablets（Tylox） and Oxycodone Hydrochloride Prolonged-Release Tablets（OXY-contin） in the treatment of advanced cancer pain to provide the direction for clinical medication.Methods：148 patients with advanced cancer pain were treated by Tylox（n=73） or OXY-contin（n=75）.After 4 weeks of treatment,the efficacy,adverse reactions and cost-effect ratio were evaluated and compared between the two groups.Results：The effective rates was 86.3% in Tylox group and 90.7% in OXY-contin group without significant difference（P0.05）.The incidence of adverse reactions in Tylox group was lower than that in OXY-contin group.The cost-effect ratio was 1861 in Tylox group and 2878 in OXY-contin group.Conclusion：The efficacy of Tylox and OXY-contin is similar.The cost-effect ratio of Tylox is lower and the adverse reactions of OXY-contin is higher.