衍生颗粒的主要药效学研究

The Experimental Study on Pharmacodynamics of Yansheng Granule

目的:验证衍生颗粒的主要药理作用。方法:使用温热药建立小鼠阴虚模型,观察衍生颗粒对该阴虚模型小鼠症状的影响,以及对该阴虚模型小鼠痛阈、体液免疫功能的影响;使用甲状腺素建立小鼠阴虚模型,观察衍生颗粒对该阴虚模型小鼠症状的影响;使用D-半乳糖和左旋甲状腺素钠建立老年阴虚大鼠模型,观察衍生颗粒对该阴虚模型大鼠症状的影响。结果:衍生颗粒对不同方法致阴虚模型动物的阴虚症状均有一定的改善作用,主要表现为明显减少阴虚小鼠的自主活动次数,降低其血浆环磷腺苷(cAMP)的含量、痛敏感性,提高免疫力,提高体重增长率,有效降低因服用甲状腺片而引发的胸腺、脾脏增长,明显改善老年阴虚大鼠低切变率下的全血黏度。结论:衍生颗粒对不同方法致阴虚模型的动物的阴虚症状均有一定的改善作用。

Objective： To verify the main pharmacological action of Yansheng granule.Method：The Yin-deficient mouse and rat models were set up by using warm-hot natured drugs,thyroxine and D-galactose and levothyroxine sodium,respectively,in order to observe the effect of Yansheng granule on the syndromes the pain threshold and humoral immunologic function of mouse.Result： In the Yin-deficient mouse model induced by Warm-hot natured drugs,Yansheng granule could decrease the autonomous locomotor activity,reduce Cyclic Adenosine Monophosphate（cAMP） in plasma and pain sensitivity,and enhance immunologic function.In the Yin-deficient mouse model induced by thyroxine,Yansheng,granule could significantly decrease the autonomous locomotor activity,increase body weight growth rate and reduce the growth of thymus and spleen.Yansheng granule could significantly improve whole blood viscosity of rats under low shear rate,but there was no significant influence about plasma viscosity.Conclusion： Yansheng granule could improve the symptoms of animal Yin-deficient models.The results of our experiment could provide some theoretical and experimental evidence for the clinical application of this medicine.