新型载体经皮凝胶剂的研究进展

Development of Transdermal Gels with Novel Drug Carriers

目的:对几种新型载体在经皮凝胶剂中的研究与应用进行文献整理和归纳。方法:通过查阅近20年经皮凝胶剂的相关文献,阐述几种新型载体的含义、特点及其凝胶剂经皮给药的实验性研究,比较它们与其他剂型经皮吸收的效果,归纳总结了几种新型载体凝胶经皮给药的研究近况,并提出了其在中药复方凝胶剂中的应用思路。结果:新型载体凝胶剂相对于普通凝胶剂及其他经皮给药剂型,有更强的渗透皮肤能力,能提高药物的稳定性,具有缓释性和靶向性。结论:目前,新型药物载体在经皮凝胶剂中的运用主要集中在几种常用载体和治疗皮肤疾病的药物上,随着研究的深入,必将拓宽到更多的新型药物载体和治疗非皮肤疾病的药物。新型载体凝胶剂给改善中药复方外用制剂带来启发和思考并有望在中药复方新剂型中得到应用。

Objective： To sort and summarize the literatures about the studies and applications of several novel drug carriers in transdermal gels.Method： Literatures about transdermal gels around 20 years were consulted to summarize the developmental state of transdermal gels with novel drug carriers.Definitions,characteristics of several novel drug carriers were explained and the effects of these new type transdermal gels were compared with other transdermal preparations to give some suggestions and improvements to the application of traditional gels of traditional Chinese medicine compounds.Result： Compared with traditional gel preparation and other transdermal administrations,the transdermal gels with novel drug carriers were more effective in penetrating skin.They could enhance the stability of drugs and make the active components targeting and sustained-release.Conclusion： The use of novel drug carriers was focused on several common carriers and the drugs treating skin diseases nowadays.More novel drug carriers and drugs treating non-skin diseases would be included in the researches about transdermal gels in the future.The transdermal gel with novel drug carriers has comprehensive area of application in transdermal administration,and give more inspirations and thinkings to topical preparations of TCM compounds.