附子白及同方配伍规律与应用条件探析

Study on Applicable Conditions and Compatibility Rules of Aconiti Lateralis Radix Preparata and Bletillae Rhizoma in Same Prescription

目的:附子、白及配伍规律与应用条件的研究。方法:在"中国中医药数据库"84 464首方剂中,共检索出含附子白及处方27首,对其主治、病机、配伍规律进行分析。结果:发现处方一致的病机是阳虚寒凝,瘀血阻滞。配伍规律是温阳散寒,开通道路,乌附为君;祛腐生肌敛疮,白及、白蔹为通用药;祛风解表,白芷、防风为首;活血化瘀,以当归、川芎为先;调畅气机,以木香、杏仁常用;清热解毒,以大黄、黄芩为佐。推测祛风散寒与活血化瘀药物能缓解附子、白及配伍产生的毒副作用,白芷与当归可能是附子、白及配伍的"解毒药"。结论:附子、白及并非绝对的相反,在一定配伍条件下可以应用。

Objective： Study on applicable conditions and compatibility rules of Aconiti Lateralis Radix Preparata and Bletillae Rhizoma in the same prescription.Method： There were 84464 herbal prescriptions of traditional Chinese medicine,among which twenty-seven herbal prescriptions contained aconite and salep.The author analyzed their functions and mechanisms and regularity of application.Result： By analyzing 27 prescriptions that contained Aconiti Lateralis Radix Preparata and Bletillae Rhizoma,we found that the pathogenesis of all the recipes were Yang deficiency,coagulated cold and blood stasis.Compatibility rules were as follows.Aconiti Lateralis Radix Preparata was used as a sovereign drug to warm Yang,dispel cold and clear the way.Bletillae Rhizoma and Ampelopsis Radix were commonly used for eliminating slough,promoting granulation and astringing sores.Radix Angelicae Dahuricae and Saposhnikoviae Radix were primarily applied to dispel pathogenic wind and resolve superficies.Angelicae Radix Sinensis and Rhizoma Ligustici were used to activate blood and dissolve stasis.Radix Aucklandiae and Semen Armeniacae Amarum were usually applied to harmonize and regulate the Qi activity.Radix et Rhizoma Rhei and Scutellariae Radix were used as a supplementary drug to clear heat and toxin.So we inferred wind-expelling and cold-removing drugs as well as blood-activating and stasis-dissolving drugs might attenuate toxicity originated from Aconiti Lateralis Preparata compounding with Bletillae Rhizoma.Angelicae Dahuricae Radix and Angelicae Sinensis Radix might be an＇antidote＇ to Aconiti Lateralis Preparata compounding with Bletillae Rhizoma.Conclusion： It is not opposite absolutely because the aconite and salep can be used together under reasonable condition.