内皮源性微粒的多面性

Study on Endothelial Microparticles

内皮源性微粒是具有复杂的囊泡性结构，来源于激活或凋亡的内皮源性细胞。它们在凝血、炎症、内皮功能和血管新生中具有显著的作用，干扰血管的动态平衡，促进血管相关性疾病形成。在血管性疾病患者中，内皮源性微粒水平增高，它们能作为反应内皮功能的生化标记物。内皮微粒被发现可以推进细胞生存、发挥抗炎效应、抗凝血过程、诱导内皮再生，因此内皮微粒是有害的观点受到挑战。这被称为内皮微粒在血管动态平衡中的矛盾作用。

Endothelial microparticles （EMP） are complex vesicular structures and derived from activated or apoptotic endothelial cells. They play a significant role in coagulation, inflammation, endothelial function and angiogenesis, disturb the vascular homeo- stasis and contribute to the progression of vascular diseases. Elevated levels of EMP are found in the patients with vascular diseases, so they can be a surrogate marker of endothelial function. Studies show that EMP can promote cell survival, exert anti - inflammatory effects, counteract coagulation processes and induce endothelial regeneration. All of them are reviewed in this paper.