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氨磺必利的合成 被引量：10

Synthesis of Amisulpride
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摘要 4-乙酰胺基-2-甲氧基苯甲酸甲酯经浓硫酸磺化、水解、氯化、还原后与溴乙烷反应,再水解得到3-乙基磺酰基-4-氨基-6-甲氧基苯甲酸,最后与1-乙基-2-氨甲基吡咯烷在三乙胺和氯甲酸乙酯作用下缩合制得抗精神分裂症药氨磺必利,总收率约61%。 Amisulpride, a novel atypical antipsychotic drug, was synthesized from methyl 4-acetamido-2- methoxybenzoate by sulfonation with sulfuric acid, hydrolysis, chlorination, reduction, reaction with bromoethane and then hydrolysis to give 3-ethylsulfonyl-4-amino-6-methoxybenzoic acid, which was subjected to condensation with 1-ethyl-2- （aminomethyl） pyrrolidine in the presence of triethylamine and ethyl chloroformate. The overall yield was about 61%.
作者 程玉红 康江鹏 陈蔚 罗振福 孙波
机构地区 天津理工大学化学化工学院 天津药物研究院化学制药部
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2011年第11期801-803,共3页 Chinese Journal of Pharmaceuticals
关键词 氨磺必利 抗精神分裂症药 合成 amisulpride antipsychotic drug synthesis
分类号 R971.41 [医药卫生—药品]
  • 相关文献

参考文献9

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二级参考文献14

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共引文献13

同被引文献113

  • 1王东波,兰利民,徐松泉,刘火荣,蔡进伟.抗精神病药物所致药疹的回顾性调查[J].药物流行病学杂志,1995,4(4):208-210. 被引量：2
  • 2袁洞君,阳利龙,祝文兵,何周康.HPLC法测定人血浆中舒必利浓度及其人体药动学和相对生物利用度研究[J].儿科药学杂志,2006,12(3):4-6. 被引量：6
  • 3黄伟侨,朱军,陈彩云,刘伟忠.高效液相色谱法测定人血浆中氨磺必利的浓度[J].中国医院药学杂志,2007,27(9):1192-1194. 被引量：4
  • 4穆殿平,刘新.卡马西平健康人体药物动力学特性[J].中国药师,2007,10(10):960-962. 被引量：3
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引证文献10

二级引证文献61

中国医药工业杂志
2011年 第11期

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