微波促进(R)-萘普生消旋反应

Microwave-accelerated Racemization of(R)-Naproxen

用微波辐射技术,以葡甲胺为催化剂、水为溶剂,于800 W功率下回流反应100 min,成功对(R)-萘普生进行消旋,收率为95%。方法操作简单,反应时间短,后处理简便。

The racemization of （R）-naproxen was achieved with meglumine as the catalyst in water under microwave irradiation （800 W） and refluxed for 100 min with a yield of about 95 %.