性激素六项在女性精神分裂症患者诊断中的应用

The Application of Six Items of Sex Hormones on Diagnosis of Female Schizophrenia Patients

目的比较月经周期正常女性精神分裂症患者治疗前与健康对照组及治疗前、后血清睾酮(TSTO)、促卵泡成熟激素(FSH)、垂体泌乳素(PRL)、孕酮(PRGE)、黄体生成素(LH)及雌二醇(E26III)的含量差异。方法采用化学发光法,收集40例月经周期正常女性精神分裂症患者未用药的检查结果,用药1月后测定结果及健康对照组数据进行比较。结果患者组(治疗前)与正常组比较PRL、E26III、PRGE组与其对照组差异有统计学意义(P<0.05),TSTO、FSH、LH组无统计学意义(P>0.05);患者组治疗前后比较,FSH、PRL、PRGE、E26III组与其对照组差异有统计学意义(P<0.05),TSTO、LH组无统计学意义(P>0.05)。结论女性血清PRL、PRGE、E26III含量检测对于女性精神分裂症的诊断、疗效评价有较好的临床意义。

Objective To compare the normal menstrual cycle before treatment of female patients with schizophrenia and healthy control group and treatment before and after the serum testosterone （TSTO）, follicle-stimulating hormone （FSH）, pituitary prolactin （PRL）, progesterone （PRGE）, luteinizing hormone （LH） and estradiol （E26 III） differences in the content. Methods A retrospective study for the collection of the normal menstrual cycle, 40 cases of female patients with schizophrenia did not use the test results.,One monthafter medication, the results were determined to compare the data of health control group. Results The patients group （before treatment） compared with the normal group, PRL, E26 III, PRGE group with the control group were statistically significantly different （P 0.05）, TSTO, FSH, LH group was not significant （P 0.05）; patients compared before and after treatment, FSH, PRL, PRGE, E26III group with the control group were statistically significantly different （P 0.05）, TSTO, LH group was not significant （P 0.05）. Conclusion Detection of PRL, PRGE, E26 III levels in serum of female patients has better clinical significance in diagnosis and effect evaluation of female schizophrenia.