PSAD用于前列腺癌危险因素分析的价值

Value OF PSAD In Analyzing the Risk Factors Of Prostate Cancer

[目的]探讨血清前列腺特异性抗原密度（PSAD）与前列腺癌危险因素之间的相关性,评估其用于分析前列腺癌危险因素的价值.[方法]检测70例前列腺癌患者血清前列腺特异性抗原（PSA）水平,利用经直肠B超测定患者的前列腺体积,根据PSA与前列腺体积的比值计算出PSAD,依据PSAD值将其分为：0.01～0.15,0.16～0.20,0.21～0.5 和大于0.51 ng/（mL·cm3）四组.根据Gleason评分和临床分期将以上70例患者分为低、中、高危三组,分别分析PSAD与Gleason评分、临床分期之间的相关性.[结果]PSAD与Gleason评分、临床分期呈显著正相关,随着PSAD的升高,前列腺癌的危险度也相应升高（P〈0.05）;同时,PSAD值升高,其骨显像阳性率也相应升高.[结论]PSAD可作为临床参考指标用于前列腺癌危险因素的分析。

[Objective] To explore the relationship between serum prostate specific antigen density（PSAD） andrisk factors of prostate cancer in order to assess the value of PSAD in analyzing the risk factors of prostate cancer. [Methods] Serum prostate specific antigen（PSA） levels of 70 patients with prostate cancer were measured. Transrectal B-ultrasound was used to detect the patienfs prostate volume, and then PSAD was calculated by the ratio of PSA to prostate volume. According to PSAD value, all patients were divided into 0.1-0. 15ng/（mL ·cm^3） group, 0.16-0.20 ng/（mL·cm^3 ） group, 0.21-0.5 ng/（mL· cm^3 ） group and more than 0.51 ng/（mL · cm^3 ） group. According to the Gleason score and clinical stage, above 70 patients were divided into low-risk group, medium-risk group and high-risk groups. The relationship between PSAD and Gleason score and clinical stage were analyzed. [Results] PSAD was positively related to Gleason score and clinical stage. With the increasing of PSAD, the risk of prostate cancer also elevated（ P 〈0.05）. Meanwhile, with the increasing of PSAD, the positive rate of bone scan increased correspondingly. [Conclusion] As a clinical reference for the analysis of risk factors of prostate cancer, PSAD can be used to judge the prognosis of prostate cancer.