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神经节苷脂对弥散性脑损伤模型大鼠认知功能的改善作用研究 被引量:1

Improvement Effect of Ganglioside on Cognitive Function of Rats after Diffuse Brain Injury
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摘要 目的:研究神经节苷脂对弥散性脑损伤模型大鼠认知功能的改善作用。方法:取大鼠48只,随机分为正常对照组、假手术组、模型组和药物干预组(神经节苷脂40mg·kg-1·d-1),每组12只,后2组均按Marmarou方法建立弥散性脑损伤模型,建模后30min各组经腹腔注射相应药物;给药14d后,采用Morris水迷宫试验和跳台试验比较各组大鼠的认知功能。结果:与正常对照组和假手术组比较,模型组和药物干预组大鼠搜索安全平台次数明显减少,在靶像限活动时间、跳台潜伏期均明显缩短,第1次穿过平台时间、跳台错误次数明显增加(P<0.05);与模型组比较,药物干预组上述指标均发生改善(P<0.05)。结论:弥散性脑损伤对大鼠认知能力有一定影响,神经节苷脂可改善弥散性脑损伤模型大鼠的认知障碍。 OBJECTIVE: To investigate the improvement effect of ganglioside on cognitive function of rats after diffuse brain injury. METHODS: 48 rats were randomly divided into normal control group, sham operation group, model group and drug intervention group (ganglioside 40 mg.kg-1.d -1) with each group of 12 rats. The diffuse brain injury model of model group and drug intervention group were established by Marmarou method. 30 min after modeling, each group was given intraperitoneally corresponding drugs. After 14 days, Morris water maze and step-down test were used to compare cognitive functions among those groups. RESULTS : Compared with normal control group and sham operation group, the times of cross safety island in model group and drug intervention group decreased significantly. The time of targeting orthant and incubation period decreased significantly, while the time of crossing island at the first time and the number of step-down errors increased significantly (P〈0.05). Compared with model group, above indexes of drug intervention group were all improved (P〈0.05). CONCLUSION: Diffuse brain injury may influence the cognitive function of rats. Ganglioside is effective in the recovery of cognitive ability.
出处 《中国药房》 CAS CSCD 北大核心 2011年第45期4248-4250,共3页 China Pharmacy
关键词 弥散性脑损伤 神经节苷脂 大鼠 Morris水迷宫试验 跳台试验 认知功能 Diffuse brain injury Ganglioside Rats Morris water maze test Step-down test Cognitive function
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  • 1Radahmadi M,Alaei H,Sharifi MR,et al.Preventive and therapeutic effect of treadmill running on chronic stress-induced memory deficit in rats[J].J Bodyw Mov Ther,2015,19(2):238.
  • 2Alkadhi KA,Tran TT.Chronic stress decreases basal levels of memory-related signaling molecules in area CA1 of at-risk(subclinical)model of alzheimer’s disease[J].Mol Neurobiol,2015,52(1):93.
  • 3Datson NA,Speksnijder N,Mayer JL,et al.The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus[J].Hippocampus,2012,22(2):359.
  • 4Day JJ,Sweatt JD.Epigenetic mechanisms in cognition[J].Neuron,2011,70(5):813.
  • 5Morgado-Bernal I.Learning and memory consolidation:linking molecular and behavioral data[J].Neuroscience,2011,10(176):12.
  • 6Iordache F,Constantinescu A,Andrei E,et al.Histone acetylation regulates the expression of Hox D9 transcription factor in endothelial progenitor cells[J].Rom J Morphol Embryol,2015,56(1):107.
  • 7Barichello T,Generoso JS,Sim?es LR,et al.Sodium butyrate prevents memory impairment by re-establishing BDNF and GDNF expression in experimental pneumococcal meningitis[J].Mol Neurobiol,2015,52(1):734.
  • 8Rosa E,Fahnestock M.CREB expression mediates amyloidβ-induced basal BDNF downregulation[J].Neurobiol Aging,2015,36(8):2 406.
  • 9方松,余化霖.Morris水迷宫实验中海马相关空间学习记忆的研究进展[J].国际病理科学与临床杂志,2010,30(4):321-326. 被引量:75
  • 10吴枫,孔令韬,汤艳清.氟西汀和碳酸锂对慢性应激抑郁模型大鼠海马脑源性神经营养因子表达的影响[J].中国全科医学,2012,15(18):2055-2058. 被引量:7

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