米非司酮配伍米索前列醇用于瘢痕子宫早孕人工流产术的效果观察

Curative Effect Observation of Mifepristone Combined with Misoprostol in Induced Abortion of Early Pregnancy in women with Scarred Uterus

目的探讨米非司酮配伍米索前列醇用于瘢痕子宫早孕妇女人工流产术的价值。方法 186例瘢痕子宫早孕要求终止妊娠的妇女随机分为试验组(n=96)和对照组(n=90),观察两组的手术效果。试验组术前2天开始服用米非司酮75mg qd,手术当天早晨口服米索前列醇600ug,待阴道流血后开始手术,对照组直接行人工流产术。结果试验组的手术时间,出血量,以及子宫穿孔和人流不全的发生率均明显低于对照组(P<0.05),差异有统计学意义,试验组优于对照组。结论米非司酮配伍米索前列醇用于瘢痕子宫早孕人工流产术手术时间短,出血量少,子宫穿孔及人流不全的并发症发生率低,值得临床推广。

Objective To discuss the application of mifepristone combined with misoprostol in induced abortion of early pregnancy in women with scarred uterus.Methods 186 cases with scarred uterus in early pregnancy were randomly divided into 2 groups： experiment group and control group,90 in each;mifepristone was administrated to patients in experiment group from 2 days before abortion,75mg once and once a day while 600ug of misoprostol of oral administration was added in the morning on the operative day;after vaginal bleeding started,the abortion was made;induced abortion was performed on patients in control group directly.Results The operation time,the bleeding volume and the occurrence of uterine perforation and incomplete induced abortion in experiment group were much lower than those in control group（P〈0.05）,the difference was of statistical significance.Conclusions The application of mifepristone combined with misoprostol in induced abortion of early pregnancy in women with scarred uterus can reduce the operation time,the bleeding volume and the occurrence of uterine perforation and incomplete induced abortion.