Menin蛋白和细胞周期素D1在甲状旁腺肿瘤中的表达及临床意义

Expression and clinical significance of Menin and cyclin-D1 in parathyroid tumor

目的探讨Menin蛋白与细胞周期素D1(Cyclin-D1)在甲状旁腺肿瘤发生中的作用及临床意义。方法 27例标本包括正常甲状旁腺组织4例,甲状旁腺增生组织6例,甲状旁腺腺瘤组织17例。通过免疫组织化学法检测它们中Menin蛋白和Cyclin-D1的表达,并进行分组比较。结果腺瘤组Menin的表达低于正常组及增生组(P<0.05),正常组同增生组比较差异无统计学意义(P>0.05)。腺瘤组Cyclin-D1的表达高于正常组及增生组(P<0.05),正常组同增生组比较差异无统计学意义(P>0.05)。结论 Menin蛋白的失活可能在甲状旁腺肿瘤的发生中起重要作用;而Cyclin-D1基因的过度表达也与甲状旁腺肿瘤的发生有关。

[Objective] To explore the function and clinical significance of Menin and cyclin-D1 in parathyroid adenoma. [Methods] The expression of the Menin protein and cyclin-D1 were determined by immunohistochemistry in 4 cases of normal parathyroid tissue, 6 cases of parathyroid proliferation tissue and 17 cases of parathyroid adenoma tissue. [Results] The expression of Menin protein and cyclin-Dlwas significantly different between normal parathyroid and parathyroid adenoma （P 〈0.05）, and was not significantly different between normal parathyroid and parathyroid proliferation （P 〉0.05）. [Conclusion] Firstly, the inactivation of Menin protein would be play an important role in the development of parathyroid tumor; Secondly, over-expression of cyelin-D1 is related to the occurrence of parathyroid tumor.