腺苷蛋氨酸治疗药物性淤胆型肝炎84例疗效分析

Therapeutic effect of ademetionine in treatment of patients with cholestatic hepatitis induced by drugs 84 cases

目的探讨腺苷蛋氨酸对药物性淤胆型肝炎的疗效。方法将84例药物性淤胆型肝炎患者分为两组。治疗组和对照组各42例。对照组用综合治疗(不加用其他任何退黄的药物),治疗组在综合治疗的基础上加用腺苷蛋氨酸1.0g,溶于5%葡萄糖溶液100ml中静脉滴注,每日1次,疗程均为4周。结果两组患者症状、体征的恢复无明显差异(P>0.05)。治疗组皮肤瘙痒、大便发白的有效率分别为73.8%(31/42)、90.4%(38/42),对照组为40.4%(17/42)、47.8%(20/42),治疗组肝损伤恢复情况优于对照组,两组差异有显著性(P<0.01)。结论腺苷蛋氨酸在治疗药物性淤胆型肝炎上对改善肝脏代谢、修复损伤的肝细胞、缓解皮肤瘙痒和改善肝功能有明显疗效。腺苷蛋氨酸是目前临床治疗药物性淤胆型肝炎比较理想安全的药物。

Objective To investigate the therapeutic effect of ademetionine in treatment of pa- tients with cholestatic hepatitis induced by drugs. Methods Totally 46 patients with cholestatic hepatitis induced by drugs were randomly divided into two groups：the control group （42 patients）received combined therapy （ without any anti - eholoplania drugs） for 4 weeks, and the therapy group （42 pa- tients） received combined therapy plus ademetionine 1.0 g into 5% glucose solution 100 ml intrave- nous injection everyday for 4 weeks. Results The recovery of symptoms and signs was not significantly different between the two groups （ P 〉 0. 05 ）. The effective rates of itch of skin and white - stool were 73.8% （31/42）and 90. 4% （38/42） ） respectively in the therapy group, while 40. 4% （ 17/42 ） and 47. 8% （20/42））respectively in the control group. The recovery of liver function in the therapy group was superior to which in the control group （P 〈 0. 05 ）. There were significantly differences between the two groups （ P 〈 0.01 ）. Conclusions Ademetionine can promote Ever metabolism,repair the injury of hepatic cell, relieve itch of skin and improve liver function obviously. It is a effective and safe drug in the therapy of patients with cholestatic hepatitis induced by drugs.