组织蛋白酶B在乳腺癌中的表达及其意义

Expression of cathepsin B in human breast cancer and its significance

目的探讨乳腺癌组织中组织蛋白酶B(CB)蛋白的表达及其意义。方法采用免疫组化S-P法检测50例纤维囊性乳腺病组织、65例乳腺浸润性导管癌组织中CB蛋白表达情况,并分析其与淋巴结转移的关系。结果 CB蛋白在浸润性导管癌中的阳性表达率为87.7%(57/65),明显高于在纤维囊性乳腺病中的表达,差异有统计学意义(P<0.05);且乳腺癌患者中有淋巴结转移组CB的表达明显高于无淋巴结转移组(P<0.05)。结论 CB蛋白的异常表达与乳腺浸润性导管癌的发生、发展及浸润转移有关。

Objective To investigate the expression of cathepsin B（CB） proteins in human breast cancer and its implication. Methods By immunohistochemical S - P method, the expression of CB were detected in 50 cases of fibrocystic mastopathy and 65 cases of invasive ductal carcinom, and the relationship was analyzed between the expression of CB and lymph node metastasis. Results The pos- itive rates of CB in invasive ductal carcinom were 87.7% （ 57/65 ）, which were significantly higher than those of 50 cases of fibrocystic mastopathy （P 〈 0. 05 ）. There was higher expression in the posi- tive group of lymph node metastasis than that in the negtive group （P 〈 0. 05 ）. Conclusions Abnor- mal expression of CB is related to development,invasion and metastasis of invasive ductal carcinoma.