奥美沙坦联合依那普利对高血压患者心功能及左心室肥厚的影响

Effects of combination Olmesartan with Enalapril on cardiac function and left ventricular hypertrophy in hypertension

目的:探讨奥美沙坦联用依那普利对高血压患者心功能及左心室肥厚的影响。方法:60例高血压患者随机分为治疗组和对照组,每组患者30例,观察两组患者治疗前后的血压和心率变化情况,采用彩色超声心动图测定治疗前及治疗6个月后左心功能及左心室参数变化。结果:治疗6个月后,治疗组每搏输出量(SV)、每分输出量(CO)、左室射血分数(LVEF)均高于治疗前和对照组(P<0.05);左室收缩未期内径(LVSd)、左室舒张未期内径(LVDd)、左室心肌重量指数(LVMI)均下降,较治疗前及对照组减少,差异有统计学意义(P<0.05)。结论:奥美沙坦联用依那普利改善高血压患者心功能及左心室肥厚的作用优于单独应用依那普利。

Objective：To evaluate effects of combination Olmesartan with Enalapril on cardiac function and left ventricular hypertrophy（LVH） in hypertensive patients.Methods：60 patients with hypertension were randomly divided into treatment group and control group,and each group was 30 patients.Blood pressure and heart rate were examined every day.Cardiac function and LVH parameters were measured by the color ultrasonic cardiogram（UCG） before and after 6 months of treatment the patients.Results： The SV,CO and LVEF were increased significantly in the treatment group（P0.05）.The LVDd,LVSd and LVMI were decreased significantly in the treatment group（P0.05）.Conclusions： The combination of Olmesartan with Enalapril in hypertensive patients has better effect on left ventricular function and LVH than Enalapril alone.