四种中药对结肠小袋虫半数致死浓度的测定

Determination of LC_(50) of Four Chinese Medicines Against Balantidium coli

利用机率单位法测定了常山、五倍子、乌梅和二花水提取物对结肠小袋虫的半数致死浓度。结果表明,常山、五倍子、乌梅和二花抗结肠小袋虫2h半数致死浓度(LC50)分别是13.40、12.22、19.02、43.34g/L;6h的LC50分别是12.80、5.824、7.619、23.32g/L;12h的LC50分别是8.275、2.762、4.012、13.90g/L。常山、五倍子和乌梅不同时间的LC50均小于相应时间二花的LC50,可作为抗结肠小袋虫候选中药。

The median lethal concentration（LC50） of the water extracts of Dichroa febrifuga,Galla chinensis,Prunus mume,Lonicera japonica against Balantidium coli were determined by probability unit method.The results showed that the median lethal concentration（LC50） of Dichroa febrifuga,Galla chinensis,Prunus mume,Lonicera japonica in 2 h against B.coli were 13.40,12.22,19.02,43.34 g/L,respectively,the median lethal concentration（LC50） in 6 h were 12.80,5.824,7.619,23.32 g/L,respectively,the median lethal concentration（LC50） in 12 h were 8.275,2.762,4.012,13.90 g/L,respectively.The median lethal concentration（LC50） of Dichroa febrifuga,Galla chinensis,Prunus mume were lower than that of Lonicera japonica,which were the candidate for Chinese medicines against B.coli.