CD44v6表达异常与腮腺多形性腺瘤复发的相关性研究

The relationship of abnormal expression of cd44v6 with recurrence of pleomorphic adenoma in salivary gland

目的探讨CD44v6在腮腺多形性腺瘤中的表达及其与肿瘤复发的关系。方法采用免疫组化S-P法检测10例腮腺复发多形性腺瘤复发前后的石蜡标本以及20例未复发腮腺多形性腺瘤中CD44v6的表达。结果未复发多形性腺瘤及复发前多形性腺瘤CD44v6呈强表达,二者表达没有统计学差异(P>0.05)。多形性腺瘤复发后CD44v6表达低于复发前,低于未复发多形性腺瘤,差异有统计学意义(P=0.031,P=0.008)。结论 CD44v6在复发多形性腺瘤中表达降低,CD44v6的表达变异可能与多形性腺瘤的复发有关。

Objective To study the relationship of the expression of CD44v6 with tumor recurrence in parotid pleomorphic adenoma.Methods The expression of CD44v610 of recurrent pleomorphic adenomas of parotid and 20 unrecurrent pleomorphic adenomas of parotid were measure with immunohistochemistry method.Results In both unrecurrent pleomorphic adenomas and the first operation＇s tissues of recurrent pleomorphic adenomas,the expression of CD44v6 were intensive.The difference of two groups was not statistically significant（P〈0.05）.The expression of CD44v6 in recurrent pleomorphic adenomas was decreased compared with those in the first operation＇s tissues,or unrecurrent pleomorphic adenomas.The difference was statistically significant（P=0.031,P=0.008）.Conclusion The expression of CD44v6 in recurrent pleomorphic adenomas decreases.The variation of CD44v6 expression may be correlated with the recurrence of pleomorphic adenomas.