艾司西酞普兰治疗老年期抑郁症随机对照研究

Treatment of geriatric depression with escitalopram and fluoxefine

目的比较艾司西酞普兰和氟西汀治疗老年期抑郁症的疗效和安全性。方法将符合中国精神障碍分类与诊断标准中抑郁症诊断标准的老年患者120例,随机分为艾司西酞普兰组和氟西汀组各60例,观察治疗6周。采用汉密尔顿抑郁量表(HAMD)和临床疗效总评量表(CGI)在治疗前和治疗后第2、4、6周末评估疗效。安全性评估包括不良事件、体检、实验室检查。结果艾司西酞普兰组的有效率和临床治愈率分别为87.3%和64%,氟西汀组分别为82.5%和58.6%,差异无统计学意义(P>0.05)。艾司西酞普兰组和氟西汀组不良反应发生率分别为30.9%和30.6%(P>0.05)。结论艾司西酞普兰治疗老年期抑郁症与氟西汀的疗效相当,耐受性好,起效时间可能早于氟西汀。

Objective To investigate the efficacy and side effect of escitalopram and fluoxetine in treatment of geriatric depression.Methods 120 patients with depression were randomly divided into escitalopram group and fluoxetine group treated with escitalopram and fluoxetine for 6 weeks,respectively.The Hamilton Depression Scale（HAMD）and clinical global impression scale（CGI）were used to assess the therapeutic effect and side effect,respectively.Results The effective rate of escitalopram group and fluoxetine group were 87.3% and 82.5%,respectively.The incidence of side effect of escitalopram group and fluoxetine group were 30.9% and 30.6%,respectively.There was no significant difference between two groups in improvement rate and side effect（P〉0.05）.Conclusion Eseitalopram is as effective as Fluoxetine for the treatment of geriatric depression,and has fewer side effect and fast onset than Fluoxetine.