101株鲍曼不动杆菌的耐药性分析

Analysis of drug resistance of acinetobacter baumannii

目的了解鲍曼不动杆菌的临床分布及其对常用抗生素的耐药状况,为有效的临床治疗和医院感染控制提供实验室依据。方法对2008年4月～2009年6月间某院分离出的101株鲍曼不动杆菌通过微量稀释法进行MIC测定。结果101株鲍曼不动杆菌大多分离自痰液,主要来自于ICU病房。鲍曼不动杆菌对复方新诺明耐药率最高,为91%,依次是环丙沙星89%,庆大霉素86%、头孢噻肟86%等。结论:我院鲍曼不动杆菌耐药情况严重,治疗首选碳青霉烯类抗生素,其次可选用替卡西林/克拉维酸、头孢哌酮/舒巴坦。

Objective To investigate the distribution and drug resistance of Acinetobacter baumanii.Methods The minimum inhibitory concentrations（MIC） of 101 acinetobacter baumannii isolated were measured by microdilution method.Results 101 Acinetobacter baummanii were mainly isolated from ICU,and most of them were from sputum.Antimicrobial susceptibility tests showed the resistant rate of Acinetobacter baumannii to TrimethoprimSulfamethoxazole was the highest（91%）,followed by gentamicin（86%）,cefotaxime（86%）.Conclusion The drug resistance of Acinetobacter baummanii is serious.Carbapenem is the preferred antibacterial therapy for Acinetobacter baumannii.