摘要
目的：探讨西肽普兰合并喹硫平治疗抑郁症的疗效和安全性。方法：将72例抑郁症患者随机分为两组（各36例）。研究组以西肽普兰合并喹硫平治疗，对照组单用西肽普兰治疗，两组疗程均为8周。采用汉密尔顿抑郁量表（HAMD）和临床总体评定量表（CGI）评定临床疗效，采用不良反应量表（TESS）评定不良反应。结果：两组治疗前后HAMD和CGI-S1分值比较差异均有统计学意义（PO.05）。结论：西肽普兰合并喹硫平比单用西肽普兰对抑郁症有更好的的治疗效果。
Objective To study the effect and safety of citalopram combined with quetiapine in the treatment of depression. Methods A total of 72 patients were randomly divided into citalopram combined with quetiapine group and citalopram group. All patients were evaluated by Hamilton Depression Rating Scale（HAMD）,Clinical Global Impression（CGI）and Treatment Emergent Symptom Scale（TESS）for 8 weeks. Results The scores of HAMD and CGI-SI had significant differences before and after treatment in two groups（P〈0.05）, and the significant differences were found between two groups too（P〈0. 05）. Side effects were no significant differences in two groups. Conclusion A combination of citaiopram and quetiapine has better efficacy than citalopram for treating depression.
