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循环microRNA作为肿瘤的非侵入性生物标志物 被引量：5

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摘要 microRNA（miRNA）是一类长度约为22个核苷酸的非编码RNA,通过和靶mRNA的3＇端非翻译区（3＇untranslated re-gion,3＇UTR）互补结合诱导靶mRNA的翻译抑制或剪切降解。miRNA表达量的变化和人类多种肿瘤的发生密切相关。肿瘤相关miRNA一般分为肿瘤抑制因子样的miRNA（tumor-suppressive miRNA）和原癌miRNA（oncogenic miRNA）。这些miRNA不仅在肿瘤发生和转移中发挥重要作用,
作者 梁宏伟 陈熹 曾科 张辰宇
机构地区 南京大学医药生物技术国家重点实验室
出处 《临床检验杂志》 CAS CSCD 北大核心 2011年第7期508-510,共3页 Chinese Journal of Clinical Laboratory Science
基金 国家自然科学基金(30950100)
关键词 循环miRNA 肿瘤诊断 生物标志物
分类号 R450 [医药卫生—治疗学]
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共引文献1056

同被引文献21

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引证文献5

二级引证文献24

临床检验杂志
2011年 第7期

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