摘要
目的探讨转录因子KLF4对结肠癌生物学行为影响的分子机制。方法收集58例手术切除的结肠癌组织标本,同时取58例相应癌旁组织作为对照。运用免疫组织化学检测结肠癌组织、癌旁组织中KLF4蛋白的表达情况。结果 58例结肠癌组织中KLF4的阳性表达率为20.7%,癌旁阳性率为75.9%。KLF4蛋白表达与患者性别、年龄、大体类型之间无显著相关(P>0.05),与结肠癌有无淋巴转移及临床分期之间呈显著相关(P<0.05)。随着不同临床分期的增加,KLF4表达逐渐下调,且有淋巴结转移的KLF4表达明显低于无淋巴结转移组。结论 KLF4与结肠癌的发生、临床进展、转移密切相关,其可能成为结肠癌治疗、预后判断的潜在生物学指标。
Objective To investigate the expression of the KLF4 protein in the colon carcinoma and its significance.Method The expression of the KLF4 was detected by immunohistochemical in 58 case of gastric carcinoma tissue.Result The positive rate of the KLF4 in gastric carcinoma was 20.7%,the KLF4 expression was not significantly corrective with the sex,age,the histology type（P0.05）,but it was associated with advanced clinical stage and with lymph node metastasis.Conclusion KLF4 may play an important role in the proliferation,and metastasis of colon carcinoma,and it could be a indicator in the diagnosis and prognosis of colon carcinoma.
出处
《中国医药指南》
2011年第31期19-20,共2页
Guide of China Medicine
