在不同气温条件下高血压病患者发生脑梗死的急性期血压与近期预后的关系

Relationship between the short-term outcome and blood pressure during acute stage of cerebral infarction in patients with hypertension under different air temperature

目的:探讨在不同气温条件下,合并有高血压病的颈内动脉系统脑梗死患者急性期的收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)与其近期预后的关系。方法:260例颈内动脉系统急性脑梗死合并高血压病患者按照起病前7 d的平均气温分3组,(1)低温组(平均气温<15℃)(n=99)。(2)常温组(平均气温15～28℃)(n=70)中。(3)高温组(平均气温>28℃)(n=91)入院后每8小时监测血压1次共10d。急性脑梗死近期预后用病程第14天的NIHSS评估。SBP、DBP、MAP与其近期预后的关系进行多元线性相关分析。结果:低温组和常温组患者病程第2天到第5天的MAP、SBP、DBP与其近期预后负相关,其中第3天MAP、SBP、DBP与近期预后的相关性最为显著(均P<0.01)。而高温组患者急性期血压与近期预后无明显相关性(均P>0.05)。结论:在低温和常温条件下,颈内动脉系统脑梗死合并高血压痛患者急性期第2天到第5天的血压与近期预后明显相关。

Objective To investigate the relationship between the short-term outcome and contractive blood pressure （SBP）, diastolic bloodpressure （DBP） ,mean arterial pressure （MAP） during acutestageofcerebral infarction （internal carotid artery system） in patients with hypertension under different air temperature. Methods Two hundred and sixty acute cerebral infarct patients with hypertension were divided into 3 groups by the mean air temperature 7 days before the onset of acute cerebral infarct： low temperature group （mean air temperature 〈 15℃, n = 99）, common temperature group （mean air temperature 15-28℃,n = 70）, high temperature group （mean air temperature 〉 28℃,n = 91 ）. Blood pressure was measured every 8 hours for l0 days. Meanwhile, the short-term outcome was evaluated by NIHSS in the 14th day at hospitalization, and its correlation with SBP, DBP, and MAP were analyzed by multivariable correlation analysis. Results SBP, DBP, and MAP were negatively correlated with NIHSS at day 2-5 in low temperature group and common temperature group, especially at day 3 （P 〈 0.01）. In high temperature group, there was no correlation between MAP, SBP, DBP and NIHSS. Conclusion In low temperature or common temperature, there was a positive correlation between BP at day 2-5 and the short-term outcome of acute cerebral infarction （internal carotid artery system） patients with hypertension.