转化生长因子-β1和斑块稳定性与动脉粥样硬化性脑梗死关系的研究

Correlation between TGF-β1 and stability of carotid plaque and atherosclerotic cerebral infarction

目的:探讨转化生长因子-β1(TGF-β1)和颈动脉斑块稳定性与动脉粥样硬化性脑梗死(ACI)的关系。方法:对发病72 h内住院经头颅CT和(或)MRI检查证实为ACI患者78例(A组)、无症状颈动脉斑块患者46例(B组)和健康对照者28例(C组)进行研究,采用彩色多普勒超声仪检测颈动脉斑块的情况,用ELISA法检测血浆TGF-β1含量。结果:A组斑块以脂质型斑块(60.9%)为主,B组以纤维钙化型(56.6%)为主;A组的TGF-β1水平显著低于B组和C组(P<0.001)。结论:TGF-β1参与影响颈动脉斑块稳定性,在ACI发病机制中发挥重要作用。

Objective To explore the correlation between TGF-βl and stability of carotid plaque and atherosclerotic cerebral infarction （ACI）. Methods Seventy-eight patients with ACI （Group A）, 46 patients with asymptomatic carotid atheroselerosis （Group B）, and 28 controls （Group C） were colleeted for the study. The serum levels of TGF-β1 were measured by ELBA, while the carotid plaque echogenicity was evaluated bilaterally by duplexdoppler ultrasound. Results The serum level of TGF-β1 in Group A was significantly lower than those in Group B and C （P 〈 0.001 ）. Fatty plaque （60.9%） was the main type of plaque in Group A, while fibrous plaque （56.6%） was frequently seen in group B. Conclusion TGF-β1 is associated with the stability of carotid plaque and plays a key role in the pathogenesis of ACI.