影响急性淋巴细胞白血病患儿首次化疗效果的Logistic多因素回归分析

Logistic regression analysis of risk factors of affecting first time chemotherapy result in children with acute lymphocytic leukemia

目的:探讨影响儿童急性淋巴细胞白血病(ALL)首次化疗结果的因素分析为临床治疗提供依据。方法:对华中科技大学同济医学院附属同济医院儿科139例ALL患儿首次化疗的有关指标与化疗效果(完全缓解或非完全缓解)的关系进行单因素和Logistic多因素分析。结果:单因素结果提示除年龄及外周血白细胞计数与首次化疗CR有关,其余各项变量均与首次化疗CR无关。Logistic多因素分析显示,外周血白细胞计数(OR=-0.636,95%CI为0.30～0.95,P=0.003)是导致儿童ALL首次化疗非完全缓解的主要危险因素。结论:对于伴外周血高白细胞的儿童ALL,其首次化疗完全缓解率较低,应引起医师的高度重视。

Objective To inwvestigate the risk factors of complete remission of childhood acute lymphoblastic leukemia （ALL） during the first time chemotherapy, so as to provide theoretical evidence for clinical treatment. Methods Totally 139 children with ALL, who were treated in our hospital during Jan. 2000 to July 2009, were included in the present study.The relations between related indices of the first time chemotherapy and complete remission were analyzed by univariate and multivariate analysis. Results Single-factor analysis showed that the age of patients and peripheral white blood cell count were the risk factors, Multivariate Logistic regression analysis showed peripheral blood white blood cell count was the main risk factor （OR = -0.636, 95% CI = 0.30-0.95 ,P = 0.003）. Conclusions High peripheral blood white blood cell count level was a risk factor of complete remission in childhood ALL which should be cared.