XPD基因多态性与DNA加合物及肿瘤易感性的研究进展

Progress in the Researches on the Association Between XPD Polymorphisms and DNA-adducts and Susceptibility to Cancer

着色性干皮病互补基团D(XPD)蛋白在核苷酸切除修复和DNA转录过程中起重要作用。研究提示2个常见的XPD多态性(Asp312Asn和Lys751Gln)与DNA损伤修复能力差异有关。而DNA修复能力增强对DNA加合物损伤的修复、铂类药物耐药起关键作用。目前XPD基团多态性与肿瘤的发病风险之间仍存在分歧,但基因-基因、基因-环境交互作用影响较为显著。

Xeroderma pigmentosum group D plays an important role in nucleotide excision repair and gene transcription. It has been confirmed that the two genetic polymorphisms in XPD （Asp312Asn and Lys751Gln） may influence DNA damage repair capacity （DRC）. High DRC may result in powerful efficiency of repairing DNA- adducts damage and strong drug resistance to platinum-based chemotherapy. At present, there is still inconsistent of the association between XPD polymorphisms and susceptibility to cancer. But the interaction of gene-gene or gene-environment analysis has been shown statistical significance on cancer susceptibility.