摘要
The importance of stochasticity in cellular processes is increasingly recognized in both theoretical andexperimental studies.General features of stochasticity in gene regulation and expression are briefly reviewed in thisarticle,which include the main experimental phenomena,classification,quantization and regulation of noises.Thecorrelation and transmission of noise in cascade networks are analyzed further and the stochastic simulation methodsthat can capture effects of intrinsic and extrinsic noise are described.
基金
Supported by the Ministry of Science and Technology of China under Grant No. 2012CB934001
the National Natural Science Foundation of China under Grant No. 10975019
the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Personnel of China under Grant No. MOP2006138
the Fundamental Research Funds for the Central Universities, and Y1515530U1
